Intervention and mechanism of exercises on primary osteoporosis

doi:10.3969/j.issn.2095-4344.0151

Abstract

Abstract:

BACKGROUND: With the acceleration of aging population in the world, the prevalence of primary osteoporosis is increasing. Complications induced by primary osteoporosis will be a key public health problem, so its prevention and treatment is an issue of concern in the medical field.
OBJECTIVE: To clarify the benign intervention mechanism of exercises on primary osteoporosis, and to analyze the mechanism of exercise effects on primary osteoporosis by literature and logical thinking methods, so as to find out the benign intervention mechanism, thereby providing theoretical reference for the patients and surgeons.
METHODS: A computer-based online search was conducted in Elsevier Science-direct, Medline, EM, CNKI, and CJFD databases using the key words of “sports, osteoporosis, nutrition, hormone, depression” in English and Chinese, respectively. The search years ranged from 1990 to 2015. Totally 756 relevant articles were screened, and 52 eligible articles were finally included for analysis and discussion.
RESULTS AND CONCLUSION: Primary osteoporosis is affected by hormone, nutrition, exercise, lifestyle and psychological factors. Exercises can mediate the secretion of hormones to regulate bone mass, which is a kind of direct physical stimulation to bone metabolism, further affecting the absorption of nutrients to maintain bone mass. Exercise makes active effect on lifestyle and psychology, thus affecting bone health. Therefore, the scientific and reasonable exercise has a benign intervention action on primary osteoporosis, and can be used to prevent primary osteoporosis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Weight-Bearing, Osteoporosis, Estrogens, Thyroxine, Biomechanics, Tissue Engineering

CLC Number:

R318

Chen Xin-lin. Intervention and mechanism of exercises on primary osteoporosis [J]. Chinese Journal of Tissue Engineering Research, 2018, 22(8): 1294-1299.

Figures/Tables 2

References

[1] Gómez C A,Ara I,González-Agüero A,et al.Effects of Training on Bone Mass in older Adults:a Systematic Review.Sports Med.2012;42(4): 25-301.

[2] Bailey C A,Brooke W K.Exercise for Optimising Peak Bone Mass in Women.Proc Nutr Soc.2008;67(1) : 9-18.

[3] 李红娟,王正珍,严翊.体力活动与骨健康[J].北京体育大学学报, 2012,35(8):37-42.

[4] 周勇,李靖,陈一冰,等.太极推手锻炼与补钙对绝经女性骨密度的影响[J].中国运动医学杂志,2005,24(1):106-108.

[5] 王春燕,何成奇.骨质疏松症治疗中的运动疗法[J].中国组织工程研究,2013,17(37):6657-6663.

[6] 宋桦.太极拳锻炼对原发性骨质疏松症患者骨密度及骨代谢的影响[J].体育学刊,2008,15(11):106-108.

[7] Cann CE, Martin M ,Genant HK ,et al.Decreased spinal mineral content in amenorrheic women.the journal of American Medical Association.1984;251(5):626-629.

[8] Kerschan-Schindl K,Uher E ,Kainberger F, et al.Long-term home exercise pr-ogram;Effect in women at high risk of fracture.Arch Phys Med Rehabil.2000;81(3):319-323.

[9] 汪继兵,严圆圆.绝经后骨质疏松症的运动处方研究[J].南京体育学院学报:自然科学版,2013,12(5):17-24.

[10] 耿红梅,郑陆,阎守扶.运动-雌激素-骨代谢关系的研究进展[J].首都体育学院学报,2008,20(5):57-60.

[11] 张文平.体育锻炼对绝经期妇女雌激素、骨代谢和骨密度的影响[J].现代康复,2000,4(9):1326-1327.

[12] 杜新星,张明军,苟波,等.太极柔力球运动对围绝经期女性雌激素及骨代谢指标的影响[J].西安体育学院学报, 2014,31(4): 459-463.

[13] Damien E,Price JS,Lanyon LE.Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females.Bone Miner Res.2000;15: 2169-2177.

[14] Li CY,Jee WS,Chen JL,et al.Estrogen and “Exercise” have a synergistic effect in preventing bone loss in the lumbar vertebra and femoral neck of the ovariectomized rat.CalcifT issue Int.2003;72:42-49.

[15] Ohlsson C,Vandenput L.The role of estrogens for male bone health.Eur J Endocrinol.2009;160(6): 883-889.

[16] 李天乐.太极拳练习对男性中老年体成分和睾酮及骨密度影响的研究[D].宁波:宁波大学,2015.

[17] 王峰.关于降钙素降低骨质疏松性骨折发病率的临床分析[J].中国实用医药,2015,10(2):163-164.

[18] Grimston SK, Tanguay KE, Gundberq CM, et al.The calciotropic hormone response to changes in serum calcium during exercise in female long distance runners.J Clin Endocrinol Metab. 1993;76:867-870.

[19] EI Hadidy el HM,Ghonaim M,EI Gawad SSh,et al.Impact of severity,duration,and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men.BMC Endocr Disord.2011;11(1):15.

[20] 杨艳,李蓬秋,朱显军.重组人甲状旁腺激素(1-34) 和依降钙素治疗原发性骨质疏松症的随机对照研究[J].中国骨质疏松杂志, 2014,20(2):139-140.

[21] Ljunghall S.Increase in serum parathyroid hormone levels after prolonged physical exercise.Med Sci Sports Exerc. 1998;20:122-125.

[22] 程翔,吴卫兵.运动对骨骼影响的激素调节[J].南昌高专学报, 2006,66(5):111-113.

[23] 王忻,郭征,李靖.比较脊髓损伤及制动后大鼠骨密度与生物力学变化的差异[J].中国组织工程研究与临床康复,2009,13(33): 6439-6442.

[24] YU Wenchao,LIU Yan,YUAN Wen,et al.Histomorphometry observation on the distal femur after spinalcord injury and immobilization in rats.J Trauma Surg.2011;13(5):446-450.

[25] Leblanc AD,Schneider VS,Evans HJ,et al.Bone mineral loss and recovery after 17 weeks of bed rest.J Bone Miner Res. 1990;23(5):843-850.

[26] Boudignon BM,Bikle DD,Kurimoto P,et al.Insulin like growth factor I stimulates recovery of bone lost after a period of skeletal unloading.J Appl Physiol.2007;103(1):125-131.

[27] Giangregoria L,Blimkie CJR.Skeletal adaptations to alteratrons in weight bearing activity a comparison of models of disuse osteoporosis.Sports Med.2002;32(7):459-476.

[28] 李军汉,黄雷.被动运动和电刺激预防废用性骨质疏松的骨代谢指标研究[J].北京体育大学学报,2009,32(8):54-56.

[29] 高俊,张前德,胡继红,等.废用性骨质疏松动物模型发生骨质疏松时间段的研究[J].江苏医药,2012,24(10):1145-1147.

[30] 吴晨,谢吟灵,史晓.老年废用性骨质疏松症的发病机制探讨[J].医学综述,2013,19(22):4148-4150.

[31] Frost HM.Skeletal structure adapations to mechanical usage( SATMU):1.Redefining Wolff law:the bone modeline problem.Anat Rec.1990;226(4):403-413.

[32] Kemper A,Ng T,Duma S.The biomechanical response of human bone: the influence of bone volume and mineral density.Biomed Sci Instrum.2006;42:284-289.

[33] 马克昌.骨生理学[M].郑州:河南医科大学出版社, 2000: 241, 272-274.

[34] 丁真奇,张喜贵,沙漠.叩击式骨应力刺激仪预防废用性骨质疏松的实验研究[J].中国骨质疏松杂志,2010,32(2):120-124,119.

[35] Frost HM.Why do marathon runners have less bone than weight lifters? AVita-biomechanical view and explanation. Bone.1997;20:183-189.

[36] 杨路昕,郭郡浩,蔡辉.运动干预原发性骨质疏松症:不同运动方式、强度及频率对骨密度的影响[J].中国组织工程研究,2014, 18(38):6200-6204.

[37] Chilibeck PD.Exercise and estrogen or estrogen alternatives(phytoestrogens,bisphosphonates) for preservation of bone mineral in postmenopausal women.Can J Appl Physioi.2004;29(1):59-75.

[38] 朱生根,廖玉兰.废用性骨质疏松症发病机制的研究进展[J].中国骨质疏松症杂志,2013, 19(12):1311-1314.

[39] 张健,赵斐,张勇.雌激素、运动与绝经后骨质疏松症[J].沈阳体育学院学报,2009,28(3:67-69, 73.

[40] Chen NX,Ryder KD,Pavalko FM,et al.Ca2+ regulates fluid shear induced cytoskeletal reorganization and gene expression in osteoblasts.Am J Physiol Cell Physiol.2000;278: 989-997.

[41] Kapur SB,aylink DJ,Lau KH.Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways. Bone.2003;32:246-251.

[42] 庞炜,于小迪,康乐,等.NO供体对大鼠成骨细胞的增值和分化及BMP-2表达的影响[J].西北国防医学杂志,2012,33(6):647-650.

[43] Donahue SW, Galley SA, Vaughan MR, et al.Parathyroid hormone may maintain bone formation in hibernating black bears (Ursus americanus) to prevent disuse osteoporosis. J Exp Biol. 2006 ;209(Pt 9):1630-1638.

[44] Turner AG,Anderson PH,Morris HA.Vitamin D and bone health.J Clin Lab Invest Suppl.2012;243(4):65-72.

[45] 田野.运动性骨骼肌结构机能变化的机制研究-力竭运动对线粒体钙代谢水平的影响[J].中国运动医学杂志,1993,12(1):31-33.

[46] 章明放,张乃鑫,谭郁彬.运动对雌性大鼠去势后骨质疏松的作用-骨组织形态计量学观察[J].中华骨科杂志,1994,14(6):365.

[47] 熊鹰.运动对绝经后骨折女性血钙、血磷、尿钙、尿磷的影响[J].浙江体育科学,2004,26(2):81-83.

[48] Yoon V,Maalouf NM,Sakhaee K.The effects of smoking on bone metabolism.Osteoporos Int.2012;23(8):2081-2092.

[49] Polymeris A,Michalakis K,Sarantopoulou V.Secondary underlying mechanisms.Endocr Regul.2013;47(3):137-148.

[50] 刘云发,陶萍,石丽杰.不同生活方式对60-69岁老年人骨密度的影响[J].沈阳体育学院学报,2013,32(5):99.

[51] 赵桂增,程瑞换,介崇崇,等.太极拳运动对中老年人轻度抑郁症影响的研究[J].中国疗养医学,2015,24(5):452-454.

[52] Cizza G.Major depressive disorder is a risk factor for low bone mass,central obesity,and other medical condition.Dialogues Clin Neurosci.2011;13(1):73-87.